黃良榮 (David L. Hwang)
Peer Reviewed Research Papers
Patents:
Peer Reviewed Research Papers
- DL Hwang, DE Foard, CH Wei. A soybean trypsin inhibitor-crystallization and X-ray crystallographic study. J. Biol. Chem. 252:1099-1101, 1977.
- DL Hwang, KTD Lin, WK Yang, DE Foard. Purification, partial characterization and immunological relationships of multiple low molecular weight protease inhibitors of soybean. Biochem. Biophys. Acta 495:369-382, 1977.
- DL Hwang, WK Yang, KTD Lin, DE Foard. Rapid release of protease inhibitors from soybeans-immunochemical quantitation and parallels with lectins. Plant Physiol. 61:30-34, 1978.
- WK Yang, DL Hwang, JO Kiggans, Jr., DM Yang, CD Stringer, DJ Moore, FC Hartman. In vitro association of selective tRNA species with 28S rRNA of mouse cells. Biochem. Biophys. Res. Comm. 80:443-450, 1978.
- WK Yang, DL Hwang. In vitro selective bindings of tRNA to rRNA of vertebrates. In: Transfer RNA: Biological aspects. Eds. D Soil, JN Abelson and PR Schimmel. Cold Spring Harbor Laboratory, N.Y. pp. 517-537, 1980.
- KTD Lin, DL Hwang, DE Foard. Affinity chromatographic interactions of proteases with low-molecular-weight soybean protease inhibitors. J. Chromatography 195:385-391, 1980.
- G Barseghian, A Lev-Ran, DL Hwang, Z Josefsberg. Fenfluramine inhibits insulin secretion and potentiates glucagon release by the perfused rat pancreas. European J. Pharmacology 96:53-59, 1983.
- G Barseghian, C Tomkinson, DL Hwang, A Lev-Ran. Effect of Corticosterone on carbamylcholin-, leucine-, or calcium-induced insulin secretion by the perfused rat pancreas. Endocrinology 114:1086-1089, 1984.
- A Lev-Ran, DL Hwang, J Josefsbery, G Barseghian, M Kemeny, M Meguid, D Beatty. Binding of epidermal growth factor and insulin to human liver microsomes and golgi fractions. Biochem. Biophys. Res. Comm. 119:1181-1185, 1984.
- Z Josefsberg, BI Carr, DL Hwang, G Barseghian, C Tomkinson, A Lev-Ran. Effect of 2-acetylamino fluorene on the binding of epidermal growth factor to microsomal and golgi fractions of rat liver cells. Cancer Research 44:2754-2757, 1984.
- A Lev-Ran, Z Josefsberg, BI Carr, G Barseghian, DL Hwang. Effect of hepatocarcinogen 2-acetylamino fluorene (2-AAF) on insulin binding to microsomal and golgi fraction of rat liver cells. J. Natl. Cancer Inst. 73:505-509, 1984.
- Barseghian, T Papoian, DL Hwang, A Roitman, A Lev-Ran. Ethanolamine mimics insulin effects in vitro. Biochem. Biophys. Res. Comm. 121:413-419, 1984.
- DL Hwang, T Papoian, Z Josefsberg, G Barseghian, A Lev-Ran. Absence of down-regulation of insulin receptors in human breast cancer cells cultured in serum-free medium: comparison with epidermal growth factor. J. Receptor Res. 5:27-43, 1985.
- DL Hwang, G Barseghian, A Lev-Ran. Determination of free insulin in antibody containing sera: comparison of polyethylene glycol and staphylococuss aureus cells. Hormone Metabolic Res. 17:595-597, 1985.
- DL Hwang, YC Tay, G Barseghian, A Roitman, A Lev-Ran. Effect of Triton x-100 on insulin and epidermal growth factor receptor binding and autophosphorylation in golgi fractions and partially purified receptors from rat liver. J. Receptor Res. 5:367-380, 1985.
- G Barseghian, I Zak, DL Hwang, A Roitman, A Lev-Ran. In vitro effect of ethanolamine on insulin secretion. Life Science 38:645-651, 1986.
- DL Hwang, A Roitman, BI Carr, G Barseghian, A Lev-Ran. Insulin and epidermal growth factor receptors in rat liver after administration of the hepatocarcinogen 2-acetylaminofluorene: ligand binding and autophosphorylation. Cancer Res. 146:1955- 1959, 1986.
- DL Hwang, A Roitman, A Lev-Ran, BI Carr. Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors. Biochem. Biophys. Res. Comm. 135:501-506, 1986.
- A Roitman, A Lev-Ran, BI Carr, DL Hwang, G Barseghian. Binding of growth hormone to rat liver golgi membrane in the course of chemical carcinogenesis. Endocrinology 118:1869-1871, 1986.
- DL Hwang, YC Tay, SS Lin, A Lev-Ran. Expression of epidermal growth factor receptors in human lung tumors. Cancer 58:2260-2263, 1986.
- DL Hwang, YC Tay, A Lev-Ran. Chromium associated 32P-labeling of proteins. Biochem. Biophys. Acta 882:331-336, 1986.
- BI Carr, A Roitman, DL Hwang, G Barseghian, A Lev-Ran. Effects of the hepatocarcinogen diethylnitrosamine (DEN) on the receptor binding and autophosphorylation of epidermal growth factor and insulin in rat liver membrane fractions. J. Natl. Cancer Inst. 77:219-225, 1986.
- A Lev-Ran, DL Hwang, G Barseghian, LR Hill. Control in non-insulin-dependent diabetes is not correlated with endogenous insulin secretion. Diabetes Metabolism 12:325-328, 1986.
- A Lev-Ran, BI Carr, DL Hwang, A Roitman. Binding of EGF and insulin and the autophosphorylation of their receptors in hepatomas caused by carcinogens. Cancer Res. 46:4656-4659, 1986.
- A Lev-Ran, DL Hwang, G Barseghian. Experimental diabetes in rats decreases the expression of EGF receptors in liver. Biochem. Biophys. Res. Comm. 137:258-262, 1986.
- A Lev-Ran, M Johnson, DL Hwang, J Askanazi, C Weissman, M Gersovitz. Double-blind study of glycerol vs glucose in parenteral nutrition of post-surgical insulin-treated diabetic patients. J. Parenteral Enteral Nutrition 11:271-274, 1987.
- DL Hwang, A Lev-Ran, T Papoian, WK Beech. Insulin-like activity of chromium-binding fractions from brewer's yeast. J. Inorg. Biochem. 30: 219-225, 1987.
- DL Hwang, A Lev-Ran, YC Tay. Hepatocarcinogens induce decrease in mRNA transcripts of receptors for insulin and epidermal growth factor in the rat liver. Biochem. Biophys. Res. Comm.146:87-93, 1987.
- A Lev-Ran, DL Hwang. Spontaneous diabetes and obesity in outbred mice. In: Frontiers in diabetes research-lessons from animal diabetes, Vol. II, Eds. E Shafrir and AE Renold. John Libbey and Co. pp. 327-329, 1988.
- A Lev-Ran, DL Hwang, CR Chen. Subdiabetogenic doses of alloxan and endogenously formed nitrosamine failed to cause vertically transmitted diabetes in mice. Horm. Metabol. Res. 20:595-596, 1988.
- DL Hwang, A Lev-Ran, YC Tay, CR Chen, N. Dev. Epidermal growth factor excretion and receptor binding in diabetic rats. Life Sciences 44:407-416, 1989.
- A Lev-Ran, DL Hwang, CR Chen, M Wimer. Palatable food option does not affect weight and glucose tolerance in adult outbred mice. Diab. Nutri. Metabol. 2:315-317, 1989.
- A Lev-Ran, DL Hwang, D. Snyder. Human serum and plasma have different sources of epidermal growth factor. Am. J. Physiol. 259:R545-R548, 1990.
- DL Hwang, A Lev-Ran. Infusion of epidermal growth factor in mice: organ distribution and urinary excretion. Regul. Peptides 29:103-108, 1990.
- DL Hwang, A Lev-Ran, YC Tay, P DeMeyts. Hepatotoxicity induced by diethylnitrosamine causes no significant disturbances of systemic glucose homeostasis in rats. Horm. Metabol. Res. 22:462-466, 1990.
- A Lev-Ran, DL Hwang, B Ahmad, H Bixby. Immunoreactive EGF in serum, plasma, platelets and urine in patients on chronic dialysis. Nephron 57:462-466, 1990.
- A Lev-Ran, DL Hwang. Epidermal growth factor in blood and urine of athyreotic adults. Clin. Physiol. Biochem. 8:184-187,1990.
- DL Hwang, A Lev-Ran. Epidermal growth factor in serum, urine, submandibular glands and kidneys of diabetic mice. Life Sciences 47:679-685, 1990.
- A Lev-Ran, DL Hwang. Epidermal growth factor and platelet- derived growth factor in blood of diabetic patients: Another aspect of platelet dysfunction. Acta Endocrinologica 123:326-330, 1990.
- A Lev-Ran, DL Hwang, J Miller, Z Josefsberg. Excretion of epidermal growth factor (EGF) in diabetes. Clin. Chim. Acta. 192:201-206, 1990.
- J Ben-Ezra, K Sheibani, DL Hwang, A Lev-Ran. Megakaryocyte synthesis is the source of epidermal growth factor (EGF) in human platelets. Am. J. Pathology. 137:755-759, 1990.
- DL Hwang, S Wang, RCR Chen, A Lev-Ran. Trauma, especially of the submandibular glands, causes release of epidermal growth factor into bloodstream in mice. Regulatory Peptides 34:133-139, 1991.
- DL Hwang, LJ Latus, A Lev-Ran. Effects of platelet-contained growth factors (PDGF, EGF, IGF-1 and TGFß) on DNA synthesis in porcine vascular smooth muscle cells in culture. Experimental Cell Research, 200:358-360, 1992.
- DL Hwang, A Lev-Ran, CF Yen, I Sniecinski. Release of different fractions of epidermal growth factor from human platelets in vitro: preferential release of 140 kDa fraction. Regulatory Peptides 37:95-100, 1992.
- A Lev-Ran, DL Hwang, LE Williams. Infusion of 131I-epidermal growth factor into a human: Clearance from the circulation and excretion with urine. Clinical & Experimental Pharmacology and Physiology 19:667-673, 1992.
- DL Hwang, CF Yen, JL Nadler. Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization. Am. J. Hypertension 5:700-706, 1992.
- Z Josefsberg, DL Hwang, A Lev-Ran. Serum epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) in diabetic patients below age 18. J. Pediatric Endocrinology 5:249-252, 1992.
- DL Hwang, CF Yen, JL Nadler. Insulin increases intracellular magnesium concentration in human platelets. J. Clinical Endocrinology and Metabolism 76:549-553, 1993.
- A Lev-Ran, DL Hwang. C-Peptide in NIDDM: follow up for 4-6 years. Diabetes Care 16:76-81, 1993.
- Z Josefsberg, A Lev-Ran, R Ross DL Hwang. Effects of Enalapril and Nitrendipine on the excretion of epidermal growth factor (EGF) and albumin in hypertensive non-insulin-dependent diabetic patients. Diabetes Care 18:690-693, 1995.
- A Yussim, A Lev-Ran, DL Hwang, Z Shapira. Epidermal growth factor in urine and serum after living donor kidney transplantation. Transplantation Proceedings 27:1048-1049, 1995.
- G Somlo, JH Doroshow, A Lev-Ran, DC Ahn, DL Hwang, et al. Effect of low-dose prophylactic dopamine on high-dosecisplatin-induced electrolyte wasting, ototoxicity, and epidermal growth factor excretion: a randomized, placebo-controled, double-blind trial. J Clinical Oncology 13:1231-1237, 1995.
- T Weinstein, DL Hwang, A Lev-Ran, Y Ori, A Korzets, J Levi. Excretion of epidermal growth factor in human adult polycystic kidney disease. Isr. J. Med. Sci. 33:641-642, 1997.
- A Lev-Ran, Y Yerushalmy, L Weissglas, V Pertsis, JS Ishay, DL Hwang. In most poorly controlled glyburide-treated type 2 diabetic patients drug withdrawal causes further increase in glycemia not accompanied by changes in insulin secretion. Horm. Metab. Res. 30:108-110, 1998.
- DL Hwang, S-P Huang, W-S Lan, PDK Lee. Elevated insulin, proinsulin and insulin-like growth factor-binding protein-1 in liver disease. Growth Hormone & IGF Research. 13:316-321, 2003.
- Yakar S, Bouxsein ML, Canalise E, Sun H, Gundberg C, Cohen P. Hwang D, Boisclair Y, LeRoith D, Rossen CJ. The ternary IGF complex influences bone acquisition and the skeletal response to intermittent parathyroid hormone. J. Endocrinology 189(2):289-299, 2006.
- Muzumdar RH, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. Central and opposing effects of IGF-I And IGF-binding protein-3 on systemic insulin action. Diabetes 55(10):2788-2796, 2006.
- Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 67(22):11083-11091, 2007.
- Freedland SJ, Mavropoulos J, Wang A, Darshan M, Demark-Wahnefried W. Aronson WJ, Cohen P, Hwang D, Peterson B, Fields T, Pizzo SV, Isaacs WB. Carbohydrate restriction, prostate cancer growth, and the insulin-like Growth factor axis. Prostate 68(1):11-19, 2008.
- Hwang D, Lee PD, Cohen P. Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth Horm IGF Res 18(1): 65-74, 2008.
- Anzo M, Cobb LJ, Hwang D, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating IGF axis but does not reduce tumor progression. Cancer Research 68(9):3342-9, 2008.
- Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. Functionally significant insulin-like growth factor-1 receptor mutations in centenarians. Proc Nat Acad Sci 105(9):3438-42, 2008.
- Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 4(7):e6334, 2009.
- Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 23(3):709-19, 2009.
- Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 284(30):19937-44, 2009
- Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.Cancer Res. 15:70(4):1564-72, 2010.
- Jia Y, Lee KW, Swerdloff R, Hwang D, Cobb LJ, Sinha Hikim A, Lue YH, Cohen P, Wang C. Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem. 15:285(3):1726-32, 2010.
- Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 151(1):350-7, 2010.
- Yamada PM, Mehta HH, Hwang D, Roos KP, Hevener AL, Lee KW. Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 151(12):5741-50, 2010.
- Williams NG, Interlichia JP, Jackson MF, Hwang D, Cohen P, Rodgers BD. Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis. Endocrinology. 152(1):172-80, 2011.
- Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 3:1-9, 2011.
- Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immuosorbent assay (EILSA). J. Clin Endocrinol Metab. 98(1)E77-81, 2012.
- Gordon Moody, Pedro J Beltran, Petia Mitchell, Elaina Cajulis, Young-Ah Chung, David Hwang, Richard Kendall, Robert Radinsky, Pinchas Cohen and Frank J Calzone. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. Journal of Endocrinology. 221:145–155, 2014.
Patents:
- David L Hwang, G. Barseghian, Arye Lev-Ran. Glucose Tolerance Factor and Method of Making the Same. US patent# 795977, Nov. 21, 1985, European patent # 86907204.1, Oct. 20, 1987.
- David L Hwang, Bingrong Liu. Chromium Complex with Insulin-Like Activity. US patent# 7297686B2, Nov. 20, 2007.